The Hon. Justice Innocent Umezulike Foundation is the first non-governmental organization in Africa actively researching and highlighting the life-threatening illness – SEPSIS. Sepsis is an overwhelming and life threatening inflammatory immune response as a result of infection. Sepsis arises when the body’s response to an infection injures its own tissues and organs, potentially leading to death or significant morbidity. In low resources settings of Sub-Saharan Africa, data are limited and proper detection and management of Sepsis is non-existent. According to the World Health Organization (WHO) Sepsis can be the clinical manifestation of infections acquired both in the community setting and in health care facilities. The global epidemiological burden of sepsis is difficult to ascertain. It is estimated to affect more than 30 million people worldwide every year, potentially leading to 6 million deaths. The burden of sepsis is most likely highest in low- and middle- income countries.